This combination consisting of Prebiotic, Probiotic and B-complex vitamins is a boon for gastrointestinal problems and in maintaining our general health. Probiotics replenish microbiome, destroyed by antioxidants & toxins in our body and assist in digestion, nutrient uptake and immune defense. Prebiotics are added to probiotics to encourage proliferation of the colonizing intestinal bacteria. They nourish the beneficial bacteria in the gastrointestinal tract. They also assist mineral absorption, improve bowel pH and cleanse the colon of debris. B-complex Vitamins are acting synergistically by maintaining healthy metabolism & digestive system.

Indications and Usage:
● Crohn's disease & Ulcerative colitis
● Infectious diarrhea
● Antibiotic associated diarrhea
● Traveller's diarrhea
● Irritable bowel syndrome
● Clostridium difficile diarrhea
● Immune system enhancement

About Composition:

Probiotics (Lactobacillus acidophilus + Bifidobacterium longum + Bifidobacterium bifidum + Bifidobacterium infantis):
A "probiotic" or "probiotics", are micro-organisms that are a natural, necessary, component of the digestive tract. They are beneficial to our body and an integral part of our immune system. These microorganisms form a living colony (a microbiome), that live within us and line our digestive tract, in a symbiotic (mutually beneficial) relationship with us. They work together, assisting with digestion, nutrient uptake and immune defense. This microbiome is destroyed by "antibiotics" and toxins that are present in our environment. As a result, the beneficial symmetry of the digestive lining gets disrupted. If an imbalance of the digestive flora persists, a galaxy of possible symptoms can manifest, and a progression of ailments can follow, as the immune system becomes compromised. Probiotics are recommended for all gastrointestinal problems or complaints and are absolutely essential to general health.

Prebiotics:
These are a type of soluble fibers made up of carbohydrates which are simple sugars (Ogliosaccharides) found in many vegetables. They nourish the beneficial bacteria in the gastrointestinal tract. They also assist mineral absorption, improve bowel pH and cleanse the colon of debris. Often prebiotics are added to probiotics to encourage proliferation of the colonizing intestinal bacteria.

Thiamin mononitrate:
Vitamin B₁ is a water soluble vitamin, and will be expelled through urine. Therefore, make sure to maintain a well balanced diet that can resupply the necessary amounts of Vitamin B₁ regularly.
Thiamine's main job is to convert sugar into energy. It helps oxidize sugar to produce energy to ensure proper functioning of the heart, brain, lungs and kidneys. Vitamin B₁ plays an important role in the production of red blood cells, which in turn keeps people healthy, active, and energized.
Ensures Proper Digestion: This vitamin also helps in the secretion of hydrochloric acid, which is essential for the complete digestion of food particles and significantly improve appetite and mental alertness.

Riboflavin:
Vitamin B₂, also called riboflavin help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. It also helps the body metabolize fats and proteins. It is necessary for healthy skin, hair, eyes, and liver. Riboflavin also helps the nervous system to function properly. Vitamin B₂ is required for the health of the mucus membranes in the digestive tract and helps with the absorption of iron and vitamin B₆.
In addition to producing energy for the body, riboflavin works as an antioxidant, fighting damaging particles in the body known as free radicals.

Folic acid:
Folic acid increases the appetite and stimulates the production of stomach acid for digestion and aids in maintaining a healthy liver. It is also used to form the nucleic acid of DNA and RNA. It is important for the formation of red and white blood cells. It is necessary for the proper differentiation and growth of cells and for the development of the fetus.

Mechanism of action:
Several important mechanisms underlying the antagonistic effects of probiotics on various microorganisms include the following:
● Modification of the gut microbiota
● Competitive adherence to the mucosa and epithelium
● Strengthening of the gut epithelial barrier
● Modulation of the immune system to convey an advantage to the host
Probiotics communicate with the host by pattern recognition receptors, such as toll-like receptors and nucleotide-binding oligomerization domain-containing protein-like receptors, which modulate key signaling pathways, such as nuclear factor-ĸB and mitogen-activated protein kinase, to enhance or suppress activation and influence downstream pathways.

Side Effects:
This combination has been used for a long time without any established risks.

Precautions:
● If you have short bowel syndrome, artificial heart valves or auto-immune disorders, etc., you should avoid pre-probiotics.
● If you are on medications, you should consult your doctor before taking pre-pro biotics.

Storage:
● Keep refrigerated to prolong shelf life; probiotics are living organisms that die at a faster rate when not refrigerated.
● Probiotics can lead to rapid die-off in moisture. After opening, keep them away from moisture, heat & light.
● Check expiration dates.